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Healing, Recovery & Injury Repair

TB-500 Peptide Therapy

10 mg / 3 mL vial

TB-500 mimics the active region of Thymosin Beta-4 — one of the most concentrated recovery proteins in your body. Where BPC-157 acts locally, TB-500 works systemically, supporting recovery, range of motion, and tissue repair throughout the whole body.

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What to Expect

  • Weeks 1–2Improved sleep, reduced overall stiffness, easier recovery between workouts
  • Weeks 2–4Improvements in target areas; range of motion often precedes pain reduction
  • Weeks 4–8Most meaningful gains — stubborn issues start moving, return to activity
  • Beyond 8 weeksBreak recommended; many return for periodic maintenance
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About TB-500

What is TB-500?

TB-500 is a synthetic peptide that mimics a key region of Thymosin Beta-4 — a protein your body produces naturally in response to injury. Thymosin Beta-4 is found in nearly every cell and is one of the most concentrated proteins in platelets, where it plays a central role in the body's wound-healing response.

Where BPC-157 tends to be associated with localized, focused repair, TB-500 is often described as having a more systemic recovery effect — it travels widely and supports tissues throughout the body.

Researchers have studied Thymosin Beta-4 and TB-500 for decades for their roles in tissue repair, cell migration, and recovery from injury.

Mechanisms

How It Works

TB-500 supports recovery through several mechanisms:

  • Cell migration — helps recruit repair cells to areas of injury
  • Actin regulation — supports the cellular framework involved in tissue rebuilding
  • Angiogenesis — supports new blood vessel formation in healing tissue
  • Anti-inflammatory effects — helps regulate the inflammatory response so it heals rather than lingers
  • Flexibility and range of motion — many patients report improvements even in chronic, stiff areas

Common Applications

What Patients Use TB-500 For

TB-500 is particularly valued for stubborn issues, limited blood-flow areas, and full-body recovery support during high training loads.

Chronic Soft-Tissue Issues

Issues that haven't fully resolved despite other interventions — TB-500's systemic reach often makes the difference

Low Blood-Flow Areas

Tendons, ligaments, and cartilage — areas notoriously slow to heal due to limited circulation

Full-Body Recovery

Systemic recovery support during high training loads or demanding athletic seasons

Flexibility & Range of Motion

Tight or restricted areas — many patients notice mobility improvements before pain changes

Old Injuries

Recovery from older injuries that still cause occasional flare-ups and haven't fully settled

Post-Training Recovery

Supporting the body's ability to bounce back between sessions during intensive training

Protocol

Dosing Context

TB-500 protocols vary based on goals — whether you're working through an active issue or using it for ongoing recovery support. Your clinician will determine your exact protocol.

Your 10 mg / 3 mL vial provides flexibility across loading and maintenance phases. Most clinicians recommend a break after 6–8 weeks to let your body's own systems consolidate the gains.

Typical Protocol Ranges

Loading Phase
2–10 mg / week
Frequency
1–2 injections / week
Loading Duration
4–6 weeks
Maintenance
2–5 mg every 1–2 weeks
Administration
Subcutaneous injection
Course Length
6–8 weeks

Context ranges only. Your clinician will prescribe your personalized protocol at consultation.

Timeline

What to Expect

TB-500 is patient — it works through your body's repair pathways rather than masking symptoms. Progress often feels gradual but lasting.

  • Weeks 1–2
    Systemic early effects

    Improved sleep, reduced overall stiffness, and a sense that recovery between workouts feels easier.

  • Weeks 2–4
    Target area improvements begin

    Patients typically begin to notice improvements in the specific areas they're targeting. Range of motion often improves before pain reduction does.

  • Weeks 4–8
    Most meaningful gains

    Most patients report their most meaningful improvements. Stubborn issues that had plateaued often start moving again.

  • Beyond 8 weeks
    Break & consolidate

    Most clinicians recommend a break to let your body's own systems take over. Many patients return for periodic maintenance courses.

Questions

Frequently Asked Questions

What's the difference between TB-500 and BPC-157?
Both support tissue repair, but through different mechanisms. BPC-157 is often described as more localized and protective; TB-500 as more systemic and mobilizing. Many patients use them together — available as our Wolverine blend — for complementary effects.
Is TB-500 the same as Thymosin Beta-4?
TB-500 is a synthetic fragment of the active region of Thymosin Beta-4. It captures the most clinically relevant portion of the natural molecule. The terms are sometimes used interchangeably in informal settings, but they are not identical.
Will it show up on a drug test?
TB-500 is on the World Anti-Doping Agency's prohibited list. Competitive athletes subject to WADA testing should not use TB-500. It is not typically screened for in employment drug tests.
How is it administered?
Subcutaneous injection — just under the skin — typically 1–2 times per week depending on your protocol. Most patients self-administer at home with ultra-fine insulin syringes.
How does it differ from cortisone or anti-inflammatories?
Cortisone and NSAIDs reduce inflammation by suppressing your body's inflammatory response, which can also slow long-term healing. TB-500 works upstream, helping the inflammatory response resolve productively while supporting the underlying tissue repair.
Can I use it alongside physical therapy?
Yes — and many clinicians recommend it. TB-500 supports the tissue rebuilding work that PT and rehab are designed to drive.
Are there side effects?
TB-500 is generally well-tolerated. The most commonly reported effects are mild fatigue during the first week or two (often described as "your body putting energy into repair") and minor injection site reactions.
Is TB-500 FDA-approved?
TB-500 is not an FDA-approved medication. It is prescribed off-label and prepared by licensed compounding pharmacies for individual patients.

Candidacy

Who Should Not Use TB-500

TB-500 may not be appropriate for individuals who:

  • Are pregnant or breastfeeding
  • Have an active cancer diagnosis or recent history of cancer
  • Are competitive athletes subject to WADA testing
  • Have specific contraindications identified during clinical evaluation

Your clinician will review your full health history during your consultation to determine candidacy.

Ready to Start Your
Recovery Protocol?

Book a telehealth consultation with a Naya Wellness clinician. We'll determine whether TB-500 — alone or combined with BPC-157 — is right for your goals.

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No office visit required. Available via telehealth.

TB-500 is prescribed off-label and compounded by a licensed U.S. pharmacy for individual patients. Statements on this page have not been evaluated by the FDA. Results vary. Peptide therapy is not appropriate for everyone. This page is for informational purposes only and does not constitute medical advice.

Medically reviewed by Carolyn Pampalone, MSN, FNP-BC · Last reviewed October 2026