Neurotoxin Comparison HubBotox, Dysport, Daxxify, Letybo,
Jeuveau & Xeominside-by-side, 2026
All six FDA-approved type A botulinum toxins compared head-to-head — onset, duration, dosing, cost, and which one fits your face. Honest analysis from a California-based medical clinic.
If you are weighing your options for wrinkle-relaxing injections, the landscape is more crowded than it was even three years ago. There are now six FDA-approved type A botulinum toxins available in the United States, each with subtle but meaningful differences in how fast they work, how long they last, how they spread through tissue, and what they cost.
This hub is your map to all of them. Below you will find a master comparison table covering all six products at a glance, followed by 15 detailed head-to-head articles — one for every possible pairing — so you can go deep on whichever comparison matters for your decision. We cover what each product is, who makes it, what the clinical evidence actually shows, and where they meaningfully diverge from one another.
A note on availability at Naya Wellness
Naya carries four of the six products at our Chatsworth and Santa Barbara clinics: Botox, Dysport, Daxxify, and Letybo. We do not currently offer Jeuveau or Xeomin. Comparison articles that include Jeuveau or Xeomin are written with full transparency — if one of those is genuinely the best fit for you, we will say so, and we will tell you which product we do carry comes closest clinically.
Which one should you be looking at?
If you have not been in this category before, here is the shortest possible orientation:
- Botox — the gold standard, longest track record, most predictable. The default for first-time patients.
- Dysport — fastest onset (2–3 days), spreads slightly more — well-suited for the forehead and large-area treatments.
- Daxxify — the long one. Median 6-month duration vs. 3–4 months for the rest. Costs more per visit but you visit half as often.
- Letybo — South Korea’s #1 toxin, newly FDA-approved (Feb 2024). Same 1:1 dosing as Botox, generally at a lower price.
- Jeuveau — marketed as “Newtox.” Most similar to Botox of any alternative (900 kDa, 1:1 dosing), typically 20–30% cheaper.
- Xeomin — the “naked toxin.” No accessory proteins, theoretically the lowest antibody risk. Slightly slower onset (5–7 days).
For the actual decision, the right product depends on what you are treating, how time-sensitive your need is, your budget cadence, and your previous response to neuromodulators. The detailed pairwise comparisons below walk through every relevant tradeoff.
All Six Neurotoxins, Side-by-Side
The master comparison table. All numbers based on current FDA labels and 2026 US market data. Scroll horizontally on mobile.
| Field | Botox | Dysport | Daxxify | Letybo | Jeuveau | Xeomin |
|---|---|---|---|---|---|---|
| Generic name | onabotulinumtoxinA | abobotulinumtoxinA | daxibotulinumtoxinA-lanm | letibotulinumtoxinA-wlbg | prabotulinumtoxinA-xvfs | incobotulinumtoxinA |
| Manufacturer | Allergan / AbbVie | Galderma | Revance | Hugel America | Evolus | Merz Aesthetics |
| FDA cosmetic approval | 2002 | April 2009 | Sept 2022 | Feb 2024 | Feb 2019 | 2011 |
| Onset | 3–7 days | 2–3 days | 1–4 days | 2–3 days | 2–3 days | 5–7 days |
| Median duration | 3–4 months | 3–4 months | 6 months | 3–4 months | 3–4 months | 3–4 months |
| Standard glabellar dose | 20 units | 50 units | 40 units | 20 units | 20 units | 20 units |
| Dosing ratio vs. Botox | 1:1 (ref) | ~2.5–3 : 1 | 2 : 1 | 1:1 | 1:1 | 1:1 |
| Complex size | ~900 kDa | ~500–900 kDa | 150 kDa + RTP-004 peptide | ~900 kDa | ~900 kDa (Hi-Pure) | 150 kDa (naked) |
| Typical $/unit (US 2026) | $12–$20 | $4–$7 | $14–$20 | $9–$15 | $8–$12 | $10–$15 |
| Typical glabellar treatment | $280–$320 | $250–$350 | $560–$800 | $200–$300 | $200–$280 | $200–$300 |
| Diffusion profile | Tight / precise | Broader spread | Tight / precise | Tight / precise | Tight (like Botox) | Tight / precise |
| Available at Naya | Yes | Yes | Yes | Yes | No | No |
All 15 Head-to-Head Comparisons
Every possible pairing of the six products, written as a deep-dive comparison. Tap a card to read the full article.
Quick Scenarios
If you have an event in two weeks
Speed of onset matters. Look at Dysport, Daxxify, Letybo, or Jeuveau — all of which typically show softening at 2–3 days, vs. Botox at 3–7 and Xeomin at 5–7. Read Botox vs. Dysport or Botox vs. Daxxify first.
If you hate scheduling re-treatments
Daxxify is the clear differentiator — median 6-month duration vs. 3–4 months for everything else. The cost is higher per visit but you go half as often. Start with Botox vs. Daxxify or Daxxify vs. Letybo.
If you are watching your budget
Letybo and Jeuveau are the value plays — both typically run cheaper per unit than Botox while using 1:1 dosing. For Naya patients, the in-network option is Letybo. Dysport sometimes works out cheapest per treatment despite higher unit count.
If you are concerned about antibody formation
The two most relevant comparisons are Xeomin (the “naked toxin” with no complexing proteins) and Letybo (which showed no neutralizing antibodies across the BLESS phase-3 program). Read Botox vs. Xeomin and Letybo vs. Xeomin.
If you are treating the forehead specifically
Dysport’s broader diffusion can be an advantage on large, flat areas like the forehead. For tighter, focal areas like crow’s feet or lip flips, the more precise products (Botox, Jeuveau, Letybo, Xeomin) tend to be preferred. See Botox vs. Dysport for the diffusion discussion.
If you have always used Botox and want to know if you should switch
Honest answer: probably not, unless one of the above scenarios applies to you. Botox is the most-studied, most-predictable, and most-injector-comfortable product in the category. If you have a specific reason to consider a switch — duration, cost, onset speed — the relevant pairwise comparison will tell you whether the switch is worth it.
Neurotoxin FAQ
They are genuinely different — but the differences are smaller than the marketing suggests for some pairs and larger than people realize for others. All six work via the same biological pathway (blocking acetylcholine release at the neuromuscular junction). Where they diverge is in molecular size, accessory proteins, formulation excipients, and clinical kinetics. The pairwise comparison articles walk through which differences are clinically meaningful and which are not.
No, and any clinic that tells you so is selling. Botox has the longest track record and is the safest default for first-time patients. Daxxify is objectively the longest-lasting. Dysport is objectively the fastest-onset. The “best” depends entirely on what you value most and what you are treating.
Yes — there is no medical reason you cannot alternate between products from one treatment session to the next. Tell your injector which product and dose you had previously so they can recalculate appropriately. The unit measurements are not interchangeable between products.
Because the units are defined differently. One unit of Dysport is not equivalent to one unit of Botox; the units are calibrated to each product’s own potency assay. For the same biological effect on the glabellar lines, you typically need about 2.5 Dysport units to match 1 Botox unit, while Letybo, Jeuveau, and Xeomin are dosed approximately 1:1 with Botox, and Daxxify is roughly 2:1 (Daxxify : Botox).
All six have excellent safety profiles in trained hands at appropriate doses, and all carry the same FDA boxed warning about theoretical distant toxin spread. Side effect rates in clinical trials are nearly identical across products: headache (3–11%), injection-site bruising (1–5%), and rare ptosis (under 1%). The single most important safety variable is not the product — it is the injector.
We carry the four products our medical team believes give us the best combination of clinical predictability, patient outcomes, and reasonable cost coverage across patient priorities — Botox, Dysport, Daxxify, and Letybo. If you are leaning Jeuveau, the closest analog we carry is Botox (same 900 kDa complex, same 1:1 dosing). If you are leaning Xeomin, Botox is usually the closest fit, or Daxxify if the no-albumin angle is what draws you to Xeomin specifically. We are happy to discuss in a paid consultation.
Visit Naya Wellness
Two California locations — click a card to view location details and book a paid consultation.
Chatsworth, CA
21800 Devonshire St. Suite B
Chatsworth, CA 91311
(818) 341-8888
- Serving Porter Ranch, West Hills & Calabasas
- Botox, Dysport, Daxxify & Letybo available
- Free parking · Easy freeway access
- Evening & weekend appointments
Santa Barbara, CA
601 East Arrellaga Street, Suite 101
Santa Barbara, CA 93103
(805) 308-5444
- Serving Montecito, Goleta & the South Coast
- Botox, Dysport, Daxxify & Letybo available
- Boutique setting in downtown Santa Barbara
- Same-week appointments often available
Sources
- U.S. FDA. BOTOX Cosmetic (onabotulinumtoxinA) Prescribing Information. accessdata.fda.gov
- U.S. FDA. DYSPORT (abobotulinumtoxinA) Prescribing Information. accessdata.fda.gov
- U.S. FDA. DAXXIFY (daxibotulinumtoxinA-lanm) Prescribing Information. accessdata.fda.gov
- U.S. FDA. LETYBO (letibotulinumtoxinA-wlbg) Prescribing Information. accessdata.fda.gov
- U.S. FDA. XEOMIN (incobotulinumtoxinA) Prescribing Information. accessdata.fda.gov
- U.S. FDA. Drug Trials Snapshots: LETYBO. fda.gov
- Sattler G., et al. “Onset and duration of effect of incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA in the treatment of glabellar frown lines: a randomized, double-blind study.” Clin Cosmet Investig Dermatol. 2013. PMC3789632
- Carruthers J., et al. “DaxibotulinumtoxinA for Injection for the Treatment of Glabellar Lines: Efficacy Results From SAKURA 3.” Aesthet Surg J. 2020. PMC7752211
This article is for educational purposes only and is not medical advice. Decisions about neurotoxin treatment should be made together with a licensed medical provider who has examined you.